Crlf1^tm1Wsa
Targeted Allele Detail

Summary

• Symbol: Crlf1^tm1Wsa
• Name: cytokine receptor-like factor 1; targeted mutation 1, Warren S Alexander
• MGI ID: MGI:2387956
• Synonyms: NR6^-
• Gene: Crlf1 Location: Chr8:70945808-70956731 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Crlf1^tm1Wsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55482
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of lung, kidney, head, and limbs from homozygous mutant animals did not detect gene expression. (J:55482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crlf1 Mutation: 18 strains or lines available

References

• Original: J:55482 Alexander WS, et al., Suckling defect in mice lacking the soluble haemopoietin receptor NR6. Curr Biol. 1999 Jun 3;9(11):605-8
• All: 2 reference(s)