Tbx5^tm1.1Jse
Targeted Allele Detail

Summary

• Symbol: Tbx5^tm1.1Jse
• Name: T-box 5; targeted mutation 1.1, Jonathan G Seidman
• MGI ID: MGI:2387851
• Synonyms: Tbx5-, Tbx5^del, Tbx5^delta
• Gene: Tbx5 Location: Chr5:119970733-120023284 bp, + strand Genetic Position: Chr5, 60.42 cM
• Alliance: Tbx5^tm1.1Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71845
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Tbx5^tm1Jse. The floxed exon 3 and neo cassette were removed by crossing mutant animals to the cre-expressing transgenic line TgN(EIIa-cre)C5379Lmgd. This results in deletion of the N-terminal region of the T-box encoded by exon 3. RT-PCR analysis of mutant animals detected a truncated transcript lacking exon 3. (J:71845)

Disease models

Expression

In Mice Carrying this Mutation:	189 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx5 Mutation: 28 strains or lines available

References

• Original: J:71845 Bruneau BG, et al., A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21;106(6):709-21
• All: 24 reference(s)