Clip2^tm1Gal
Targeted Allele Detail

Summary

• Symbol: Clip2^tm1Gal
• Name: CAP-GLY domain containing linker protein 2; targeted mutation 1, Niels Galjart
• MGI ID: MGI:2387832
• Synonyms: CLIP-T
• Gene: Clip2 Location: Chr5:134518237-134581288 bp, - strand Genetic Position: Chr5, 74.63 cM, cytoband G
• Alliance: Clip2^tm1Gal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78711
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The endogenous locus was targeted with two rounds of homologous recombination that inserted a floxed neomycin selection cassette into intron 2 and a cassette containing a floxed puromycin resistance gene followed by lacZ into the 3' untranslated region. Exons 3 through 17 were flanked by the floxed selection genes. The production of transcript and protein from this allele was verified by Northern and Western blot analyses. (J:78711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clip2 Mutation: 60 strains or lines available

References

• Original: J:78711 Hoogenraad CC, et al., Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat Genet. 2002 Sep;32(1):116-27
• All: 1 reference(s)