Smpx^tm1.1Rph
Targeted Allele Detail

Summary

• Symbol: Smpx^tm1.1Rph
• Name: small muscle protein, X-linked; targeted mutation 1.1, Richard P Harvey
• MGI ID: MGI:2387820
• Synonyms: Csl^APdelta, Csl^tm1.1Rph
• Gene: Smpx Location: ChrX:156481969-156535587 bp, + strand Genetic Position: ChrX, 72.67 cM
• Alliance: Smpx^tm1.1Rph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69803
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is derived from Smpx^tm1Rph by crossing mutant animals to a cre-expressing line, TgN(CMV-cre)1Cgn. The floxed exon 2 and neo cassette were removed by cre-mediated recombination leaving behind the remainder of the construct, the human placental alkaline phosphatase gene (ALPP). Western blot analysis of heart and muscle extracts from homozygous mutant animals did not detect protein expression. Alkaline phosphatase expression was noted in a similar expression pattern to the endogenous protein. (J:69803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smpx Mutation: 3 strains or lines available

References

• Original: J:69803 Palmer S, et al., The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. J Cell Biol. 2001 May 28;153(5):985-98
• All: 1 reference(s)