Tg(SERPINA1-cre/ERT)1Ipc
Transgene Detail
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Symbol: |
Tg(SERPINA1-cre/ERT)1Ipc |
Name: |
transgene insertion 1, I Pierre Chambon |
MGI ID: |
MGI:2387444 |
Synonyms: |
alphaAT-cre-ERT, Tg(SERPINA1-cre/ESR1)1Ipc |
Transgene: |
Tg(SERPINA1-cre/ERT)1Ipc Location: unknown
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Alliance: |
Tg(SERPINA1-cre/ERT)1Ipc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(SERPINA1-cre/ERT)1Ipc expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
SERPINA1 (5265) |
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Mutation details: This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes.
(J:69327)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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SERPINA1
(human)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:69327 Imai T, et al., Inducible site-specific somatic mutagenesis in mouse hepatocytes. Genesis. 2000 Feb;26(2):147-8 |
All: |
3 reference(s) |
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