Cebpa^tm1Nerl
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Nerl
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Claus Nerlov
• MGI ID: MGI:2387091
• Synonyms: 1n, BRM1
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Nerl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72330
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A partial rat Cebpa gene carring a valine to alanine substitution at position 287 (V270A) and a glutamic acid to alanine substitution at position 290 (E290A) in the basic region alpha helix replaced the corresponding portion of the mouse gene via homologous recombination. A neo resistance marker was also introduced downstream of Cepba for positive selection. (J:72330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 18 strains or lines available

References

• Original: J:72330 Porse BT, et al., E2f repression by c/ebpalpha is required for adipogenesis and granulopoiesis in vivo. Cell. 2001 Oct 19;107(2):247-58
• All: 1 reference(s)