Ripk4^tm1Pmh
Targeted Allele Detail

Summary

• Symbol: Ripk4^tm1Pmh
• Name: receptor-interacting serine-threonine kinase 4; targeted mutation 1, Pamela M Holland
• MGI ID: MGI:2387011
• Synonyms: RIP4^-, RIPK4^-
• Gene: Ripk4 Location: Chr16:97543133-97564979 bp, - strand Genetic Position: Chr16, 57.63 cM
• Alliance: Ripk4^tm1Pmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78593
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exons 2 through 7 and a portion of exon 8 were replaced by a neomycin selection cassette inserted via homologous recombination. The deleted region encoded amino acids 62 through 591. (J:78593)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk4 Mutation: 44 strains or lines available

References

• Original: J:78593 Holland P, et al., RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation. Curr Biol. 2002 Aug 20;12(16):1424-8
• All: 7 reference(s)