Ren1^tm1Gom
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1Gom
• Name: renin 1 structural; targeted mutation 1, R Ariel Gomez
• MGI ID: MGI:2386989
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1Gom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72077
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exons 1 through 7 were replaced by homologous recombination of a cassette containing GFP and neo. Southern blot analysis confirmed that the targeting vector hybridized exclusively to Ren1 and not to Ren2. RT-PCR analyses of kidney tissue confirmed the absence of endogenous transcript in homozygous mutant mice. Expression of GFP was verified in both heterozygous and homozygous mutant mice. (J:72077)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 34 strains or lines available

References

• Original: J:72077 Pentz ES, et al., Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiol Genomics. 2001 Jun 6;6(1):45-55
• All: 1 reference(s)