Cps1tm1Mw
Targeted Allele Detail
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Symbol: |
Cps1tm1Mw |
Name: |
carbamoyl-phosphate synthetase 1; targeted mutation 1, Maki Wakamiya |
MGI ID: |
MGI:2386969 |
Synonyms: |
CPSase (-) |
Gene: |
Cps1 Location: Chr1:67162185-67270418 bp, + strand Genetic Position: Chr1, 33.75 cM, cytoband C3
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Alliance: |
Cps1tm1Mw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:52334
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A PGK-neo selection cassette was inserted into exon 17, which encodes an ATP binding domain, via homologous recombination. Enzyme activity was undetected in liver extracts obtained from homozygous mutant mice, indicating a complete functional ablation of the targeted locus. Furthermore, transcript was undetected by RT-PCR analysis of total liver RNA.
(J:52334)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cps1 Mutation: |
108 strains or lines available
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Original: |
J:52334 Schofield JP, et al., Mice deficient in the urea-cycle enzyme, carbamoyl phosphate synthetase I, die during the early neonatal period from hyperammonemia. Hepatology. 1999 Jan;29(1):181-5 |
All: |
2 reference(s) |
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