Igtp^tm1Gvw
Targeted Allele Detail

Summary

• Symbol: Igtp^tm1Gvw
• Name: interferon gamma induced GTPase; targeted mutation 1, George F Vande Woude
• MGI ID: MGI:2386795
• Synonyms: IGTP-, Irgm3^-
• Gene: Igtp Location: Chr11:58090382-58098417 bp, + strand Genetic Position: Chr11, 36.01 cM
• Alliance: Igtp^tm1Gvw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59891
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.9 kb region of exon 2 encoding amino acids 13-240 was replaced with a PGK-neo derived cassette via homologous recombination. No protein product could be detected in homozygous mutant animals in any of the tissues tested by Western blot analysis. (J:59891)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igtp Mutation: 22 strains or lines available

References

• Original: J:59891 Taylor GA, et al., Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):751-5
• All: 25 reference(s)