Vcam1^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Vcam1^tm1Flv
• Name: vascular cell adhesion molecule 1; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2386555
• Synonyms: vcam-1^neo
• Gene: Vcam1 Location: Chr3:115903669-115923337 bp, - strand Genetic Position: Chr3, 50.17 cM
• Alliance: Vcam1^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68147
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The cytokine responsive promoter region and exon 1 were flanked by an upstream sinlge loxP site and a downstream floxed neo cassette. Analysis of spleen dendritic cells showed a 4 to 5 fold reduction of levels of encoded protein in samples obtained from homozygous mutant mice relative to those obtained from wild-type mice. (J:68147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcam1 Mutation: 44 strains or lines available

References

• Original: J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
• All: 1 reference(s)