Gdi1^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Gdi1^tm1Ytk
• Name: GDP dissociation inhibitor 1; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:2386302
• Gene: Gdi1 Location: ChrX:73348618-73355473 bp, + strand Genetic Position: ChrX, 37.97 cM, cytoband B-C1
• Alliance: Gdi1^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65258
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2.3 kb of sequence, encompassing exons 3 through 6, were replaced by a neomycin selection cassette inserted via homologous recombination. Western blot analysis of brain extracts showed a lack of protein produced by the targeted allele in homozygous mutant females and hemizygous males. (J:65258)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdi1 Mutation: 14 strains or lines available

References

• Original: J:65258 Ishizaki H, et al., Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11587-92
• All: 1 reference(s)