Rev3l^tm1Msn
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm1Msn
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1, Michael S Neuberger
• MGI ID: MGI:2386282
• Synonyms: mRev3^N
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm1Msn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65202
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin selection cassette disrupted an exon encoding a portion of the carboxy terminal DNA polymerase domain. (J:65202)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 118 strains or lines available

References

• Original: J:65202 Bemark M, et al., Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Curr Biol. 2000 Oct 5;10(19):1213-6
• All: 1 reference(s)