Tg(Fli1)1Ber
Transgene Detail

Summary

• Symbol: Tg(Fli1)1Ber
• Name: transgene insertion 1, Alan Bernstein
• MGI ID: MGI:2386171
• Synonyms: H-2K^k-Fli-1
• Transgene: Tg(Fli1)1Ber Location: unknown
• Alliance: Tg(Fli1)1Ber page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fli1)1Ber expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fli1 (MGI:95554)

• Mutation details: The mouse H2-K1 promoter was used to express a 1.73 kb mouse Fli1 cDNA in a wide range of tissues. RNase protection assay confirmed transgene expression in mutant animals and Western blot analysis detected transgene expression in all tissues examined. Expression of endogenous Fli1 was also found to be elevated in transgenic animals. (J:29889)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This mutation is representative of 3 transgenic founders designated as B6, B7, and B8 carrying 20, 8, and 4 copies of the transgene, respectively.

References

• Original: J:29889 Zhang L, et al., An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Mol Cell Biol. 1995 Dec;15(12):6961-70
• All: 2 reference(s)