Tapbp^tm1Gjh
Targeted Allele Detail

Summary

• Symbol: Tapbp^tm1Gjh
• Name: TAP binding protein; targeted mutation 1, Gunter J Hammerling
• MGI ID: MGI:2386113
• Synonyms: Tpn^-
• Gene: Tapbp Location: Chr17:34138452-34148264 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tapbp^tm1Gjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64349
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette in the reverse orientation into exon 4 via homologous recombination. Western blot analysis of spleen lysates from homozygous mutant animals did not detect protein product. (J:64349)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tapbp Mutation: 23 strains or lines available

References

• Original: J:64349 Garbi N, et al., Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol. 2000 Sep;1(3):234-8
• All: 3 reference(s)