Epor^tm1.1Jtp
Targeted Allele Detail

Summary

• Symbol: Epor^tm1.1Jtp
• Name: erythropoietin receptor; targeted mutation 1.1, Josef T Prchal
• MGI ID: MGI:2386088
• Synonyms: hEPOR^{flox-neo(arrow)}, wthEPOR^neo
• Gene: Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
• Alliance: Epor^tm1.1Jtp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67205
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Epor^tm1.1Jtp expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EPOR (2057)

  Epor	(MGI:95408)

• Mutation details: This allele is a derivative of Epor^tm1Jtp in which an exchange targeting vector was used to replace the PGK-Hprt minigene. The exchange vector contained the human sequence of the gene from the translational start site to the stop codon, and a floxed PGK-neomycin resistance cassette inserted in reverse orientation into intron 6. (J:67205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epor Mutation: 25 strains or lines available

References

• Original: J:67205 Divoky V, et al., Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):986-91
• All: 3 reference(s)