Bves^tm1Tbd
Targeted Allele Detail

Summary

• Symbol: Bves^tm1Tbd
• Name: blood vessel epicardial substance; targeted mutation 1, Thomas Brand
• MGI ID: MGI:2385915
• Synonyms: Pop1-LacZ, Popdc1^-
• Gene: Bves Location: Chr10:45211868-45248575 bp, + strand Genetic Position: Chr10, 23.47 cM
• Alliance: Bves^tm1Tbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74656
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing NLS-lacZ and neo genes was inserted downstream of the translational start codon in exon 2 via homologous recombination. Normal transcript was undetected by RT-PCR analysis of heart, skeletal muscle, and bladder tissue obtained from homozygous mutant mice. Although the 5' UTR and all intronic sequences were left intact, the expression of beta-galactosidase did not completely correlate with that of the endogenous gene. (J:74656)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bves Mutation: 18 strains or lines available

References

• Original: J:74656 Andree B, et al., Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Mol Cell Biol. 2002 Mar;22(5):1504-12
• All: 7 reference(s)