Ren1^tm1Mgfs
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1Mgfs
• Name: renin 1 structural; targeted mutation 1, Matthew G F Sharp
• MGI ID: MGI:2385802
• Synonyms: Ren-1^d-
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1Mgfs page

Altered renal morphology in Ren1^tm1Mgfs/Ren1^tm1Mgfs mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41714
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 92 bp of exon 3, the third intron, and 35 bp of exon 4. RT-PCR analysis of kidney did not detect mRNA. (J:41714)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 36 strains or lines available

References

• Original: J:41714 Clark AF, et al., Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. J Biol Chem. 1997 Jul 18;272(29):18185-90
• All: 2 reference(s)