Slc8a1tm1Yin
Targeted Allele Detail
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Symbol: |
Slc8a1tm1Yin |
Name: |
solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Yo-ichi Nabeshima |
MGI ID: |
MGI:2384549 |
Synonyms: |
Ncx1 - |
Gene: |
Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
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Alliance: |
Slc8a1tm1Yin page
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Slc8a1tm1Yin/Slc8a1tm1Yin embryos lack identifiable vitelline blood vessels
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:65985
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Parent Cell Line: |
A3-1 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a fragment of the gene containing most of exon 2. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele.
(J:65985)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc8a1 Mutation: |
55 strains or lines available
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Original: |
J:65985 Wakimoto K, et al., Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem. 2000 Nov 24;275(47):36991-8 |
All: |
10 reference(s) |
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