Jun^tm1Bdc
Targeted Allele Detail

Summary

• Symbol: Jun^tm1Bdc
• Name: Jun proto-oncogene, AP-1 transcription factor subunit; targeted mutation 1, Bruce D Carter
• MGI ID: MGI:2384450
• Synonyms: c-jun^fl, c-Jun^flox
• Gene: Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
• Alliance: Jun^tm1Bdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding exon of the enodogenous allele was flanked by an upstream loxP site and a downstream floxed neo cassette. Transient expression of cre recombinase in ES cells resulted in the excision of the neo cassette, leaving a floxed coding exon. (J:78265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jun Mutation: 14 strains or lines available

References

• Original: J:78265 Palmada M, et al., c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J Cell Biol. 2002 Aug 5;158(3):453-61
• All: 7 reference(s)