Ccl11^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Ccl11^tm1Brv
• Name: C-C motif chemokine ligand 11; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:2384431
• Synonyms: eotaxin^-
• Gene: Ccl11 Location: Chr11:81948658-81953781 bp, + strand Genetic Position: Chr11, 49.84 cM
• Alliance: Ccl11^tm1Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78283
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in frame insertion of lacZ after sequence encoding the first four amino acids replaced the remainder of exon 1 and all of exon 2. No endogenous transcript was detected in homozygous mutant mice via Northern blot analysis of lymph node RNA. Expression realized by Xgal staining only partially coincided with RT-PCR analysis and previous results. (J:78283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl11 Mutation: 15 strains or lines available

References

• Original: J:78283 Yang Y, et al., Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood. 1998 Nov 15;92(10):3912-23
• All: 5 reference(s)