Fgf1^tm1Bas
Targeted Allele Detail

Summary

• Symbol: Fgf1^tm1Bas
• Name: fibroblast growth factor 1; targeted mutation 1, Claudio Basilico
• MGI ID: MGI:2383991
• Synonyms: FGF1^-
• Gene: Fgf1 Location: Chr18:38971726-39062525 bp, - strand Genetic Position: Chr18, 20.74 cM
• Alliance: Fgf1^tm1Bas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60597
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and surrounding genomic sequence were replaced with a PGK-neo casstte. The absence of encoded protein in homozygous mutant mice was determined via Western blot analysis of extracts from various tissues. (J:60597)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf1 Mutation: 40 strains or lines available

References

• Original: J:60597 Miller DL, et al., Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice [published erratum appears in Mol Cell Biol 2000 May;20(10):3752]. Mol Cell Biol. 2000 Mar;20(6):2260-8
• All: 4 reference(s)