Foxd2^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Foxd2^tm1Blh
• Name: forkhead box D2; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:2183921
• Synonyms: Mf2^lacZ
• Gene: Foxd2 Location: Chr4:114763479-114766070 bp, - strand Genetic Position: Chr4, 52.73 cM
• Alliance: Foxd2^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60219
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding amino acids 92 through 262 were replaced by a cassette containing IRES-lacZ and a floxed neo. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. A stop codon upstream of the IRES precluded the translation of a fusion protein. (J:60219)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxd2 Mutation: 19 strains or lines available

References

• Original: J:60219 Kume T, et al., Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. Mol Cell Biol. 2000 Feb;20(4):1419-25
• All: 1 reference(s)