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Creb1tm4Gsc
Targeted Allele Detail
Summary
Symbol: Creb1tm4Gsc
Name: cAMP responsive element binding protein 1; targeted mutation 4, Gunther Schutz
MGI ID: MGI:2183908
Synonyms: CREBS142A
Gene: Creb1  Location: Chr1:64571963-64643707 bp, + strand  Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance: Creb1tm4Gsc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75993
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
 
Mutation detailsA serine to alanine substitution at amino acid 142 (S142A) was introduced to exon 8 and a floxed TK-neo cassette was inserted into the upstream intron via homologous recombination. Removal of the TK-neo cassette was achieved by transient expression of cre recombinase in correctly targeted ES cells. The presence of the S142A mutation was verified by sequencing of RT-PCR products from heterozygous animals. Immunohistochemistry of brain sections from homozygous mutant animals demonstrates the absence of phosphorylation at serine 142. The gene expression pattern of homozygous mutants is similar to that of wild-type animals. (J:75993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Creb1 Mutation:  59 strains or lines available
References
Original:  J:75993 Gau D, et al., Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock. Neuron. 2002 Apr 11;34(2):245-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory