Cyp11a1^tm1Bcc
Targeted Allele Detail

Summary

• Symbol: Cyp11a1^tm1Bcc
• Name: cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 1, Bon-Chu Chung
• MGI ID: MGI:2183813
• Synonyms: Cyp11a1^E1-neo
• Gene: Cyp11a1 Location: Chr9:57913694-57934306 bp, + strand Genetic Position: Chr9, 31.63 cM
• Alliance: Cyp11a1^tm1Bcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78062
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a floxed neomycin selection cassette. Western blot analysis of adrenal and testis extracts showed an absence of protein in homozygous mutant mice. (J:78062, J:191801)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp11a1 Mutation: 41 strains or lines available

References

• Original: J:78062 Hu MC, et al., Steroid deficiency syndromes in mice with targeted disruption of CYP11A1. Mol Endocrinol. 2002 Aug;16(8):1943-50
• All: 4 reference(s)