Tpi1^a-M2Neu
Chemically induced Allele Detail

Summary

• Symbol: Tpi1^a-M2Neu
• Name: triosephosphate isomerase 1; mutation 2, Neuherberg
• MGI ID: MGI:2183490
• Synonyms: TPI 2312, Tpi^2Neu
• Gene: Tpi1 Location: Chr6:124787549-124791121 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Tpi1^a-M2Neu page

Mutation origin

• Strain of Origin: (101/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T-to-A transversion at codon 192 in exon 6. This is predicted to alter a leucine to a glycine in the H6 alpha-helix on the outer surface of the protein. This mutation is identical to Tpi^m-1Neu, but arose independently. TPI1 activity in heterozygotes is 50% that of wild-type in blood; and also reduced in liver, lung, spleen, kidney, brain, heart and muscle. (J:25049)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpi1 Mutation: 23 strains or lines available

References

• Original: J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
• All: 5 reference(s)