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Targeted Allele Detail
Symbol: Plcb4tm1Dwu
Name: phospholipase C, beta 4; targeted mutation 1, Dianqing Wu
MGI ID: MGI:2183374
Synonyms: PLCBeta4-
Gene: Plcb4  Location: Chr2:135500931-135856513 bp, + strand  Genetic Position: Chr2, 66.64 cM
Alliance: Plcb4tm1Dwu page
Retinal morphology of Plcb4tm1Dwu/Plcb4tm1Dwu mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77638
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThe exon encoding the X box was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in retinal extracts and brain sections via Western blot analysis and immunohistochemical staining, respectively. (J:77638)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcb4 Mutation:  106 strains or lines available
Original:  J:77638 Jiang H, et al., Phospholipase C beta 4 is involved in modulating the visual response in mice. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14598-601
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory