Cyp26a1^tm1Ptk
Targeted Allele Detail

Summary

• Symbol: Cyp26a1^tm1Ptk
• Name: cytochrome P450, family 26, subfamily a, polypeptide 1; targeted mutation 1, Martin Petkovich
• MGI ID: MGI:2183273
• Synonyms: L3
• Gene: Cyp26a1 Location: Chr19:37686246-37689984 bp, + strand Genetic Position: Chr19, 32.36 cM, cytoband C2-C3
• Alliance: Cyp26a1^tm1Ptk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67399
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 5' to exon 2 and a loxP flanked neomycin selection cassette was inserted 3' to exon 6. (J:67399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp26a1 Mutation: 35 strains or lines available

References

• Original: J:67399 Abu-Abed S, et al., The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40
• All: 3 reference(s)