Egr2^tm3.1Pch
Targeted Allele Detail

Summary

• Symbol: Egr2^tm3.1Pch
• Name: early growth response 2; targeted mutation 3.1, Patrick Charnay
• MGI ID: MGI:2183228
• Synonyms: Krox20^delta
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm3.1Pch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75128
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Egr2^tm3Pch in which exon 2 and flanking sequences were deleted by Cre mediated recombination. Mice carrying the Egr2^tm3Pch allele were mated to Tg(Pgk1-cre)1Lni mice and offspring were screened for the heritable deletion. Immunohistochemistry experiments on homozygous embryos demonstrated that no detectable protein was encoded by this allele. (J:75128)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 32 strains or lines available

References

• Original: J:75128 Taillebourg E, et al., Conditional, floxed allele of the Krox20 gene. Genesis. 2002 Feb;32(2):112-3
• All: 1 reference(s)