Dbp^tm2Schb
Targeted Allele Detail

Summary

• Symbol: Dbp^tm2Schb
• Name: D site albumin promoter binding protein; targeted mutation 2, Ueli Schibler
• MGI ID: MGI:2183205
• Synonyms: Dbp^dim, insertion KO
• Gene: Dbp Location: Chr7:45354658-45359579 bp, + strand Genetic Position: Chr7, 29.45 cM
• Alliance: Dbp^tm2Schb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44434
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 4, which encodes the dimerization domain. Transcript produced from the targeted allele was detected via Northern blot analysis and RNA protection assay. Western blot analysis of nuclear extracts from homozygous mutant mice showed the absence of encoded protein. (J:44434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbp Mutation: 21 strains or lines available

References

• Original: J:44434 Lopez-Molina L, et al., The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J. 1997 Nov 17;16(22):6762-71
• All: 2 reference(s)