Evx1^tm1.1Gld
Targeted Allele Detail

Summary

• Symbol: Evx1^tm1.1Gld
• Name: even-skipped homeobox 1; targeted mutation 1.1, Martyn Goulding
• MGI ID: MGI:2182858
• Synonyms: Evx1^tau-myc, Evx1^tm
• Gene: Evx1 Location: Chr6:52290483-52295363 bp, + strand Genetic Position: Chr6, 25.44 cM
• Alliance: Evx1^tm1.1Gld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70192
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was generated by breeding mice heterozygous for Evx1^tm1Gld and transgenic mice expressing cre with a protamine promoter. Expression of cre excised the portion of the homeodomain encoded by exon 3 and a neo gene, leaving IRES-tau-myc in the 3' untranslated region. Analysis of transverse sections of heterozygous mutant embyros showed that the expression of tau-myc resembled that of the endogenous gene. (J:70192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evx1 Mutation: 18 strains or lines available

References

• Original: J:70192 Moran-Rivard L, et al., Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron. 2001 Feb;29(2):385-99
• All: 2 reference(s)