H1f2^tm1Ais
Targeted Allele Detail

Summary

• Symbol: H1f2^tm1Ais
• Name: H1.2 linker histone, cluster member; targeted mutation 1, Art I Skoultchi
• MGI ID: MGI:2182775
• Synonyms: H1c^-
• Gene: H1f2 Location: Chr13:23922790-23923514 bp, + strand Genetic Position: Chr13, 9.9 cM, cytoband A2-A3
• Alliance: H1f2^tm1Ais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72858
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 80% of the coding region of the gene, which includes the ATG start site, was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by reverse-phase HPLC analysis of liver histone extracts. (J:72858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H1f2 Mutation: 16 strains or lines available

References

• Original: J:72858 Fan Y, et al., Individual somatic h1 subtypes are dispensable for mouse development even in mice lacking the h1(0) replacement subtype. Mol Cell Biol. 2001 Dec;21(23):7933-43
• All: 3 reference(s)