Mnx1^tm2Tmj
Targeted Allele Detail

Summary

• Symbol: Mnx1^tm2Tmj
• Name: motor neuron and pancreas homeobox 1; targeted mutation 2, Thomas M Jessell
• MGI ID: MGI:2182361
• Synonyms: Hb9^taulacZ
• Gene: Mnx1 Location: Chr5:29678821-29683468 bp, - strand Genetic Position: Chr5, 15.04 cM
• Alliance: Mnx1^tm2Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57340
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing an IRES-tau-lacZ gene, a floxed neomycin gene, and a SV40 polyadenylation signal. The absence of encoded protein in the of homozygous mutant embryos was determined using antisera. Staining of heterozygotes showed the expression pattern of beta-galactosidase to be similar to that of the endogenous gene. (J:57340)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mnx1 Mutation: 28 strains or lines available

References

• Original: J:57340 Arber S, et al., Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999 Aug;23(4):659-74
• All: 1 reference(s)