Tg(Mt1-Il5)6Ato
Transgene Detail

Summary

• Symbol: Tg(Mt1-Il5)6Ato
• Name: transgene insertion 6, Akira Tominaga
• MGI ID: MGI:2182299
• Synonyms: IL-5 Tg
• Transgene: Tg(Mt1-Il5)6Ato Location: unknown
• Alliance: Tg(Mt1-Il5)6Ato page

Transgene origin

• Strain of Origin: C3H/HeN

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Il5)6Ato expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il5 (MGI:96557)

• Mutation details: The transgene is composed of the cadmium-inducible mouse Mt1 promoter and a mouse Il5 cDNA sequence removed of its 3' untranslated region. (J:76903)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-Il5)6Ato

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

Founder 6 carries approximately 40 copies of the transgene as determined by Southern blot analysis. Northern blot analysis confirmed expression of the transgene in liver and spleen tissues. ELIZA assays performed on homozygous cadmium-treated transgenic animals estimated the expression of the transgene to be at least 1,600-fold that of control animals.

References

• Original: J:76903 Tominaga A, et al., Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J Exp Med. 1991 Feb 1;173(2):429-37
• All: 9 reference(s)