Vdac1^tm1Wjc
Targeted Allele Detail

Summary

• Symbol: Vdac1^tm1Wjc
• Name: voltage-dependent anion channel 1; targeted mutation 1, William J Craigen
• MGI ID: MGI:2182154
• Synonyms: VDAC1^-
• Gene: Vdac1 Location: Chr11:52251905-52280224 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Vdac1^tm1Wjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76838
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.7kb fragment, containing exons 2 through 5, was replaced with a neomycin selection cassette. Northern blot analysis showed the absence of transcript in homozygous mutant mice. (J:76838, J:78058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdac1 Mutation: 64 strains or lines available

References

• Original: J:76838 Weeber EJ, et al., The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J Biol Chem. 2002 May 24;277(21):18891-7
• All: 6 reference(s)