Cfd^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Cfd^tm1Pa
• Name: complement factor D; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:2182153
• Gene: Cfd Location: Chr10:79726687-79728489 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Cfd^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70953
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis showed an absence of transcript in homozygous mutant mice. (J:70953)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfd Mutation: 21 strains or lines available

References

• Original: J:70953 Johnson RS, et al., Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science. 1989 Sep 15;245(4923):1234-6
• All: 1 reference(s)