Tg(Nfh/lacZ)44AApt
Transgene Detail

Summary

• Symbol: Tg(Nfh/lacZ)44AApt
• Name: transgene insertion 44A, Alan Peterson
• MGI ID: MGI:2182128
• Synonyms: NF-H-lacZ, NFHLacZ, NFH-LacZ
• Transgene: Tg(Nfh/lacZ)44AApt Location: unknown
• Alliance: Tg(Nfh/lacZ)44AApt page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene consists of 14.9 kb of the mouse Nfh gene (from -2.9 kb to the middle of exon 4) fused in frame to lacZ followed by an SV40 polyadenylation signal. The Nfh portion of the transgene includes the first 782 amino acids, which contains the complete N-terminal domain, central alpha-helical rod domain, and half of the C-terminal domain up to and including the 45th KSP repeat. (J:76723)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:76723 Eyer J, et al., Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Neuron. 1994 Feb;12(2):389-405
• All: 11 reference(s)