Slc14a1^tm1Ask
Targeted Allele Detail

Summary

• Symbol: Slc14a1^tm1Ask
• Name: solute carrier family 14 (urea transporter), member 1; targeted mutation 1, Alan S Verkman
• MGI ID: MGI:2182112
• Synonyms: UT-B null, UTB-null
• Gene: Slc14a1 Location: Chr18:78143306-78185334 bp, - strand Genetic Position: Chr18, 52.49 cM
• Alliance: Slc14a1^tm1Ask page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75466
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced by a neomycin selection cassette. Truncated transcript was detected via Northern blot analysis, however, immunoblot analysis of erythrocyte extracts and immunohistochemical staining of renal tissue confirmed the absence of protein in homozygous mutant mice. (J:75466)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc14a1 Mutation: 39 strains or lines available

References

• Original: J:75466 Yang B, et al., Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002 Mar 22;277(12):10633-7
• All: 11 reference(s)