Pnoc^tm1Rkr
Targeted Allele Detail

Summary

• Symbol: Pnoc^tm1Rkr
• Name: prepronociceptin; targeted mutation 1, Rainer K Reinscheid
• MGI ID: MGI:2181778
• Synonyms: OFQ/N^-, ppN/OFQ-
• Gene: Pnoc Location: Chr14:65638122-65662921 bp, - strand Genetic Position: Chr14, 34.33 cM, cytoband D1
• Alliance: Pnoc^tm1Rkr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57479
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. Gene expression was absent in homozygous mutant animals as demonstrated by immunohistochemical staining of brain sections. (J:57479)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnoc Mutation: 12 strains or lines available

References

• Original: J:57479 Koster A, et al., Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10444-9
• All: 10 reference(s)