Bace1tm1Slr
Targeted Allele Detail
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Symbol: |
Bace1tm1Slr |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Steven L Roberds |
MGI ID: |
MGI:2181643 |
Gene: |
Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
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Alliance: |
Bace1tm1Slr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:77414
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A neomycin selection cassette, flanked by FLP recombinase target (FRT) sites was inserted into intron 3. An additional FRT site was inserted into intron 8, situating exons 4 through 8 in between FRT sites. Heterozygous mice were utilized to generate mice possessing Bacetm1.1Slr.
(J:77414)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bace1 Mutation: |
27 strains or lines available
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Original: |
J:77414 Roberds SL, et al., BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 1;10(12):1317-24 |
All: |
2 reference(s) |
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