Del(19Poll-Dcpd)1Nmt
Targeted Allele Detail

Summary

• Symbol: Del(19Poll-Dcpd)1Nmt
• Name: deletion, Chr 19, Noboru Motoyama 1
• MGI ID: MGI:2181352
• Synonyms: Dpcd/Poll^tm1Nmt, Pol lambda^-
• Gene: Del(19Poll-Dcpd)1Nmt Location: unknown Genetic Position: Chr19, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75779
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(19Poll-Dcpd)1Nmt involves 2 genes/genome features (Poll, Dpcd) View all
• Mutation details: The gene was disrupted by replacement of exons 1-6 with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the translation initiation site, the BRCT motif, and half of the polymerase X domain of Poll. Homozygous mutant animals lack gene expression in testis as determined by Northern blot analysis. Analysis of the genomic region surrounding the Poll gene revealed an uncharacterized gene, named Dpcd, that is predicted to be transcribed from the opposite strand relative to Poll. The deletion of Poll also removes the first exon of Dpcd. (J:75779, J:97294)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(19Poll-Dcpd)1Nmt Mutation: 0 strains or lines available

References

• Original: J:75779 Kobayashi Y, et al., Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol. 2002 Apr;22(8):2769-76
• All: 3 reference(s)