Socs3^tm1Wsa
Targeted Allele Detail

Summary

• Symbol: Socs3^tm1Wsa
• Name: suppressor of cytokine signaling 3; targeted mutation 1, Warren S Alexander
• MGI ID: MGI:2180861
• Synonyms: SOCS3^-
• Gene: Socs3 Location: Chr11:117856905-117860192 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Socs3^tm1Wsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a construct containing lacZ and neo. The lacZ was inserted immediately after the start codon, and thus placed under control of the endogenous promoter. Northern blot analysis revealed a lack of transcript in fibroblasts isolated from homozygous mutant embryos stimulated by IFN-gamma. An absence of expression was further confirmed by RT-PCR analysis of total embryonic RNA. The lacZ expression pattern was observed to be the same in whole mount homozygous embryos as it was in heterzygotes. (J:70667)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs3 Mutation: 21 strains or lines available

References

• Original: J:70667 Roberts AW, et al., Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9324-9
• All: 12 reference(s)