Art2a^null
Spontaneous Allele Detail

Summary

• Symbol: Art2a^null
• Name: ADP-ribosyltransferase 2a; null
• MGI ID: MGI:2180366
• Synonyms: C57BL/6 Rt6-1
• Gene: Art2a Location: Chr7:101201660-101210072 bp, - strand Genetic Position: Chr7, 54.6 cM
• Alliance: Art2a^null page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: Sequence analysis of the endogenous loci of C57BL/6 and BALB/c mice revealed 9 nucleotide differences between the two backgrounds. Codon 481 on the C57BL/6 background encodes an in-frame stop signal, putatively precluding the translation of the essential glycosylphosphatidylinositol (GPI) anchor. Protein was undetected by Western blot analysis of COS1 cells transfected with the C57BL/6 variant. The absence of fucntional protein was confirmed by a lack of ADP-ribosyltransferase activity in the COS1 cells. (J:42560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Art2a Mutation: 9 strains or lines available

References

• Original: J:42560 Kanaitsuka T, et al., Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout. J Immunol. 1997 Sep 15;159(6):2741-9
• All: 2 reference(s)