Syt4^tm1Hahe
Targeted Allele Detail

Summary

• Symbol: Syt4^tm1Hahe
• Name: synaptotagmin IV; targeted mutation 1, Harvey R Herschman
• MGI ID: MGI:2180158
• Synonyms: Syt4^tm1Hrh, Syt IV -/-
• Gene: Syt4 Location: Chr18:31570861-31580459 bp, - strand Genetic Position: Chr18, 17.75 cM
• Alliance: Syt4^tm1Hahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62218
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neo resistance cassette into an exon encoding the first C2 domain. Northern blot of total brain RNA from homozygous mutant animals verified the absence of gene expression. (J:62218)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syt4 Mutation: 24 strains or lines available

References

• Original: J:62218 Ferguson GD, et al., Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5598-603
• All: 10 reference(s)