Ahsg^tm1Mbl
Targeted Allele Detail

Summary

• Symbol: Ahsg^tm1Mbl
• Name: alpha-2-HS-glycoprotein; targeted mutation 1, Manfred Blessing
• MGI ID: MGI:2180147
• Synonyms: Ahsg^-, Ahsg^tm1wja, Ahsg^tm1Wja, Fet^-, fetuin-KO
• Gene: Ahsg Location: Chr16:22710793-22718193 bp, + strand Genetic Position: Chr16, 13.74 cM
• Alliance: Ahsg^tm1Mbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44632
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 12-kb region including the entire gene and flanking regions was replaced with a neomycin cassette. Indirect ELISA showed an absence of protein in serum isolated from homozygous mutant animals. (J:44632)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahsg Mutation: 16 strains or lines available

References

• Original: J:44632 Jahnen-Dechent W, et al., Cloning and targeted deletion of the mouse fetuin gene. J Biol Chem. 1997 Dec 12;272(50):31496-503
• All: 18 reference(s)