Col1a1^tm2.1Bst
Targeted Allele Detail

Summary

• Symbol: Col1a1^tm2.1Bst
• Name: collagen, type I, alpha 1; targeted mutation 2.1, Paul Bornstein
• MGI ID: MGI:2178816
• Synonyms: exon 2delta
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^tm2.1Bst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73906
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: A floxed PGK-neomycin resistance cassette deleted exon 2 and placed a silent mutation in exon 7. Cre-mediated recombination in vivo removed the neo cassette in the germ line. The authors predict that this allele would produce a correctly spliced protein that lacks 65 amino acids, almost the entire globular domain of the N-propeptide. (J:73906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:73906 Bornstein P, et al., The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. J Biol Chem. 2002 Jan 25;277(4):2605-13
• All: 2 reference(s)