Myc^{tm1(Nmyc1)Fwa}
Targeted Allele Detail

Summary

• Symbol: Myc^{tm1(Nmyc1)Fwa}
• Name: Myc proto-oncogene, bHLH transcription factor; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2178231
• Synonyms: c-myc^neo
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^{tm1(Nmyc1)Fwa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62573
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire second exon, the coding portion of the third exon and the intervening intron were replaced with the analogous sequences from Nmyc1 gene. A loxP flanked neomycin selection cassette was also inserted in the second intron in reverse transcriptional orientation. (J:62573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:62573 Malynn BA, et al., N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 1;14(11):1390-9
• All: 1 reference(s)