Hhex^tm1Rbe
Targeted Allele Detail

Summary

• Symbol: Hhex^tm1Rbe
• Name: hematopoietically expressed homeobox; targeted mutation 1, Rosa Beddington
• MGI ID: MGI:2177762
• Synonyms: Hex-, Hex^lacZ
• Gene: Hhex Location: Chr19:37423289-37429179 bp, + strand Genetic Position: Chr19, 32.28 cM, cytoband D1
• Alliance: Hhex^tm1Rbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62027
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• An IRES-lacZ-neo cassette replaced the first three exons of the endogenous locus. (J:62027)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhex Mutation: 16 strains or lines available

References

• Original: J:62027 Martinez Barbera JP, et al., The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development. 2000 Jun;127(11):2433-45
• All: 5 reference(s)