Htt^tm2Szi
Targeted Allele Detail

Summary

• Symbol: Htt^tm2Szi
• Name: huntingtin; targeted mutation 2, Scott Zeitlin
• MGI ID: MGI:2177755
• Synonyms: Hdh^flox
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm2Szi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65520
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette followed by a loxP site was inserted 5' to exon 1 and a single loxP site was inserted 3' to exon 1. (J:65520)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:65520 Dragatsis I, et al., Inactivation of hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet. 2000 Nov;26(3):300-6
• All: 17 reference(s)