Marckstm1Pjb
Targeted Allele Detail
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Symbol: |
Marckstm1Pjb |
Name: |
myristoylated alanine rich protein kinase C substrate; targeted mutation 1, Perry J Blackshear |
MGI ID: |
MGI:2176302 |
Synonyms: |
MARCKS- |
Gene: |
Marcks Location: Chr10:37009371-37014916 bp, - strand Genetic Position: Chr10, 19.49 cM
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Alliance: |
Marckstm1Pjb page
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Coronal sections of brains from Marckstm1Pjb/Marckstm1Pjb mice at E18.5
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:22949
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A neomycin resistance gene was inserted into exon 1, 18 bp after the ATG initiation codon. Northern blot analysis on RNA derived from E18.5 embryonic heads of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on on lysates also of E18.5 embryonic heads of homozygous mice confirmed that no detectable protein was expressed from this allele.
(J:22949)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Marcks Mutation: |
13 strains or lines available
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Original: |
J:22949 Stumpo DJ, et al., MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):944-8 |
All: |
15 reference(s) |
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